Von Zumbusch’s pustular psoriasis associated with oral terbinafine

Severe Generalized Pustular Psoriasis Provoked by Oral Terbinafine

Terbinafine is an allylamine antifungal agent. Its severe cutaneous adverse effects are rare, but toxic epidermal necrolysis, pustular drug eruption, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and erythema multiforme had been reported. Terbinafine was also reported to induce flare-up of chronic psoriasis or development of pustular psoriasis. Here we report a psoriatic...

Generalized Pustular Psoriasis and Hepatic Dysfunction Associated with Oral Terbinafine Therapy

We report a case of 61-yr-old man with stable psoriasis who progressively developed generalized pustular eruption, erythroderma, fever, and hepatic dysfunction following oral terbinafine. Skin biopsy was compatible with pustular psoriasis. After discontinuation of terbinafine and initiating topical corticosteroid and calcipotriol combination with narrow band ultraviolet B therapy, patient's con...

Generalized pustular psoriasis of pregnancy treated with oral cyclosporin.

Acute Pustular Psoriasis

was stable, his skin became irritable and hot with extensive reddening. Though in bed in a warm room he felt cold. During the next three days the skin became tender, and large areas of pustulation developed. Subsequently there was widespread peeling of the skin, and crusting developed on the face and neck. On admission to hospital there was generalized cutaneous erythema and scleral jaundice. T...

Successful treatment with etanercept of von Zumbusch pustular psoriasis in a patient with human immunodeficiency virus.

Treatment of von Zumbusch pustular psoriasis is a formidable task, especially when confounded by concomitant human immunodeficiency virus (HIV) infection. To our knowledge, this is the first report of successful use of a biologic agent to treat a patient with both von Zumbusch pustular psoriasis and HIV. Given the propensity of HIV to both trigger and exacerbate psoriasis and the potentially se...